CosmosID-HUB is a cloud-based microbiome analysis platform that simplifies next-gen sequencing data analysis using various bioinformatics pipelines. Supporting data from 16S, ITS, shotgun metagenomics, and metatranscriptomics, the platform leverages cloud infrastructure to deliver rapid taxonomic and functional profiling within hours rather than weeks. Users can effortlessly create virtual cohorts via a customizable interface, enabling comprehensive comparative analyses with dynamic heatmaps, plots, statistics, and differential abundance analyses. These results can be exported in multiple formats, making CosmosID-HUB a powerful, efficient tool for detailed microbiome research and communication.

The CosmosID-HUB uses raw, unassembled reads from metagenomic sequencing (FASTQ files) as input and matches the sequence against curated reference databases for taxonomic and functional profiling. If you would prefer to watch a video that takes you through the entire process, just click here.

Access and Pricing

The CosmosID-HUB is available to any researchers with access to a web browser.

We offer monthly and yearly subscription model with per-sample analysis charges depending on the data type.

There are flexible options with a number of modules to suit your analysis needs, as well as academic pricing. Contact [email protected] for more info.

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Request a 14 day free trial here!

CosmosID-HUB Core Capabilities

1. Comprehensive Data Analysis
   1. Supports 16S rRNA, ITS, Shotgun Metagenomics, and Metatranscriptomic analysis.
   2. Automated pipelines process raw FASTQ data directly, providing high-quality taxonomic and
      functional profiling outputs.
2. Intuitive User Interface and Data Management
   1. Researchers can easily upload data, create virtual cohorts, and manage study metadata via the platform dashboard
   2. Allows generation of configurable comparative analyses, including dynamic visualizations and statistical insights for effective interpretation.
3. Scalable Cloud Computing
   1. Built on Amazon Web Services (AWS), CosmosID-HUB offers secure, scalable cloud computing with rapid data processing, handling analyses in minutes to hours depending on sample size.

Pipelines

1. CHAMP™ Human Microbiome Profiler
   1. Tailored for human-associated microbiome analysis with a proprietary phylogenetic marker-based algorithm to minimize false positives/negatives.
   2. Provides multi-kingdom taxonomic profiling informed from real-world human microbiome data, along with functional modules like Gut-Brain/Gut-Metabolic Modules and KEGG pathway outputs.
2. Kepler™ Host-Agnostic Microbiome Profiler
   1. Suitable for environmental, agricultural, and animal microbiomes using a high-precision k-mer-based identification approach.
   2. Supports taxonomic profiling across bacteria, fungi, viruses, and protists, leveraging a database of 150,000 genomes and genes encompassing >30,000 species.
3. Host-Agnostic Functional Profiling
   1. Employs an optimized HUMANN3 framework, which can also be used for metagenomic and metatranscriptomic data.
   2. Outputs include functional annotations from MetaCyc pathways, GO terms, Pfam, CAZy, and Enzyme Commission. This enables robust functional analysis, enriching insights into microbial functions across diverse environments and hosts.
4. Kepler™ Resistome & Virulome Profiler
   1. Focuses on characterizing antimicrobial resistance genes and virulence factors using ResFinder and VFDB databases.
5. 16S rRNA Amplicon Profiler
   1. Provides high-resolution bacterial community profiling using the DADA2 ASV algorithm and the SILVA 138 database, with taxonomic and predicted functional outputs.
6. ITS Amplicon Profiler
   1. Focuses on fungal communities using Internal Transcribed Spacer (ITS) sequencing with the UNITE database for accurate classification.
7. Comparative Analysis Visualization & Reporting Module
   1. Integrates alpha/beta diversity analyses, differential abundance analyses, and configurable visualizations such as heatmaps, stacked bar charts, PCA, and more, enabling user-friendly interpretation and publication-ready results.