KEPLER is a novel taxonomic profiling pipeline engineered to extract optimal value from metagenomic data. Combining the sensitivity of exact-matching and the precision and accuracy of probabilistic alignment, Kepler achieves robust identification and enumeration of microbial taxa spanning bacteria, viruses, fungi, and protists.

The core of KEPLER’s technology is patented in both the US Patent office (US10108778B2, US20200294628A1) and European Patent Office (ES2899879T3).

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How does KEPLER work?

The patented KEPLER multi-kingdom taxonomic profiler is a comprehensive algorithm consisting of three interwoven pipelines:

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KEPLER Benchmarking

The performance of KEPLER on benchmark datasets, as highlighted in our benchmark whitepaper, demonstrates its superiority in species-level identification and functional annotation. KEPLER outperformed other tools in detecting microbial species, especially in complex environments like low-biomass samples. It showed enhanced accuracy and precision in taxonomic classification across a range of sample types.

Key findings from the benchmarking include:

  • Higher Sensitivity: KEPLER was able to detect microbial species that other tools missed, particularly in datasets with lower microbial diversity.
  • Improved Speed and Scalability: Compared to competing tools, KEPLER processed larger datasets more quickly, making it suitable for large-scale studies.
  • Superior Functional Annotation: The tool provided more detailed functional profiles, linking microbial presence to potential biological functions more effectively than other systems.

To learn more about KEPLER and its benchmarking, please download the whitepaper from here.

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Cited by:

The papers have cited the Cosmos-Hub in their methodology. Consult these for examples:

You can find additional studies at our literature page.

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FAQ

To learn more about KELPER™ and its benchmarking, please download the KEPLER Benchmarking whitepaper https://cosmosidhub.com/kepler-host-agnostic-microbiome-profiler/ .