Kepler™ is a novel taxonomic profiling pipeline engineered to extract optimal value from metagenomic data. Combining the sensitivity of exact-matching and the precision and accuracy of probabilistic alignment, Kepler achieves robust identification and enumeration of microbial taxa spanning bacteria, viruses, fungi, and protists.
The core of Kepler™‘s technology is patented in both the US Patent office (US10108778B2, US20200294628A1) and European Patent Office (ES2899879T3).

How does Kepler™ work?

The patented Kepler multi-kingdom taxonomic profiler is a comprehensive algorithm consisting of three interwoven pipelines:

Kepler™ Benchmarking

The performance of Kepler on benchmark datasets, as highlighted in our benchmark whitepaper, demonstrates its superiority in species-level identification and functional annotation. Kepler outperformed other tools in detecting microbial species, especially in complex environments like low-biomass samples. It showed enhanced accuracy and precision in taxonomic classification across a range of sample types. Key findings from the benchmarking include:
  • Higher Sensitivity: Kepler was able to detect microbial species that other tools missed, particularly in datasets with lower microbial diversity.
  • Improved Speed and Scalability: Compared to competing tools, Kepler processed larger datasets more quickly, making it suitable for large-scale studies.
  • Superior Functional Annotation: The tool provided more detailed functional profiles, linking microbial presence to potential biological functions more effectively than other systems.

Read the Kepler Benchmarking Whitepaper

Cited by:

The papers have cited the Cosmos-Hub in their methodology. Consult these for examples: You can find additional studies at our literature page.

FAQ

To learn more about Kepler™ and its benchmarking, please download the benchmarking whitepaper.