Cosmos-Hub is an secure AWS-based microbiome analysis platform designed to streamline sequencing data analysis through comprehensive and automated bioinformatics pipelines. The Hub efficiently supports diverse data types, including raw, unassembled sequencing reads (FASTQ files) generated by shotgun metagenomics, metatranscriptomics, and amplicon 16S/ITS (both short-reads and long-reads), delivering precise taxonomic and functional profiling in just hours—not weeks.
New to the platform? Get a brief onboarding here
Learn about our taxonomic and functional pipelines and the use cases
Cosmos-Hub accepts raw, unassembled reads (FASTQ) files via multiple methods
Fast and comprehensive cohort analysis with our statistical toolbox
Upload data from the Command Line, and integrate our tools to your pipelines
Read the latest updates within the Cosmos-Hub
Reach our full support team for quick responses to your questions or feedback
Download your raw FASTQ files, profiling data, and comparative analyses
CHAMP™ | Human Microbiome Profiler
Tailored for human-associated microbiome analysis with a proprietary phylogenetic marker-based algorithm to minimize false positives/negatives.
Provides multi-kingdom taxonomic profiling informed from real-world human microbiome data, along with functional modules like Gut-Brain/Gut-Metabolic Modules and KEGG pathway outputs.
Pita et al. CHAMP delivers accurate taxonomic profiles of the prokaryotes, eukaryotes, and bacteriophages in the human microbiome. Frontiers in Microbiology, 2024.
Kepler™ | Host-Agnostic Microbiome Profiler
Suitable for any sample type, including environmental, agricultural, and animal microbiomes. Using a high-precision k-mer-based identification approach, Kepler supports taxonomic profiling across bacteria, fungi, viruses, and protists, leveraging a database of 150,000 genomes and genes encompassing >30,000 species.
Read our whitepaper here: Kepler Benchmarking Whitepaper
Functional | Host-Agnostic Functional Profiling
Employs an optimized humann3 framework, which can be used for metagenomic and metatranscriptomic data.
Outputs include functional annotations from MetaCyc, GeneOntology (GO), Pfam, CAZy, and EnzymeCommission databases, enabling comprehensive functional analyses across diverse microbial environments.
Kepler AMR/VF | Resistome and Virulome Profiler
Characterize antimicrobial resistance genes and virulence factors with trusted databases like ResFinder and VFDB.
DADA2 | 16S rRNA ASV Pipeline
High-resolution bacterial community profiling using the DADA2 ASV algorithm and the SILVA 138 database, providing both taxonomic and predicted functional insights.
QIIME | 16S rRNA OTU Pipeline
Utilizes the QIIME2 framework for clustering sequences based on 97% similarity threshold into Operational Taxonomic Units (OTUs) for taxonomic identification based on the SILVA v138 Database.
QIIME | ITS OTU Pipeline
Focuses on fungal communities using Internal Transcribed Spacer (ITS) sequencing with the UNITE database for accurate classification.
Comparative Analysis Visualization & Reporting Module
Integrates alpha/beta diversity analyses, differential abundance analyses, and configurable visualizations such as heatmaps, stacked bar charts, PCA, and more, enabling user-friendly interpretation and publication-ready results.
COMING SOON Enabling long-read 16S (V1-V8) profiling and analysis.
COMING SOON Enabling assembly-based profiling of metagenomic data.
The Cosmos-Hub is available to any researchers with access to a web browser.
We offer monthly and yearly subscription model with per-sample analysis charges depending on the data type.
There are flexible options with a number of modules to suit your analysis needs, as well as academic pricing. Contact info@cosmos-hub.com for more info.